Summary: Older mice did not benefit significantly from the blood of younger mice when it came to extending their lifespan. However, younger mice that were exposed to the blood of older mice had a significant reduction in lifespan.
Source: Mary Ann Liebert Inc.
A new study in which young and old mice were surgically joined to share blood circulation for three months showed that old mice did not benefit significantly in terms of lifespan.
In contrast, young mice exposed to blood from older animals had a significantly reduced lifespan compared to mice that shared blood with other young mice.
The study is published in the peer-reviewed journal Search for rejuvenation.
Heterochronic parabiosis is a research tool used to assess the effect of organs and blood-borne factors on young and old animals. Less controlled than direct blood exchange, parabiosis is a model of blood sharing between two surgically connected animals.
Iryna Pishel, of Taras Shevchenko Kyiv National University and Bienta Ltd, Kyiv, Ukraine, and her co-authors used heterochronic parabiosis between young and old mice and isochronous controls for three months.
They then disconnected the animals and studied the effects of the union on the animals’ blood plasma and lifespan.
“The most robust and interesting result of this study is the fact of a significant reduction in the lifespan of young mice from heterochronic parabiotic couples”, specify the researchers.
“These data support our hypothesis that old blood contains factors capable of inducing aging in young animals. The discovery and selective suppression of the production of aging factors in the body could be the key research area for the extension of life,” they conclude.
Editor-in-Chief Irina Conboy, PhD, Professor, College of Engineering, University of California, Berkeley says “This work clarifies the question of whether young blood or old blood controls longevity, which has been debated (Nature 2005, Conboy, et. al). Are there any lasting effects of heterochronic parabiosis and if so, is it rejuvenating or aging?
“The work of the Pishel group has established that the lifetime from old mice does not increase after being parabiosis to young mice. In contrast, young animals that have been mated to old mice suffer from a shortened lifespan, even after being mated.
“This finding is important for establishing the precise direction of anti-aging clinical approaches and for providing key scientific evidence against the potency of youthful blood factors in an aged organism.
“This work fully follows the previously published report by this group that infusions of young blood plasma in mice do not increase their lifespan (Shytikov, Search for rejuvenation)”
On a very important note, Professor Pishel conducted these fundamental studies as the head of the department at the Taras Shevchenko National University in Kyiv, while writing the article as a refugee, based on data collected before the outbreak of the war. Such important studies were interrupted by the war, and we hope that they will soon continue and produce further breakthroughs.
About this longevity research news
Author: Kathryn Rühle
Source: Mary Ann Liebert Inc.
Contact: Kathryn Ruehle – Mary Ann Liebert Inc.
Image: Image is in public domain
Original research: Free access.
“Three-month-old heterochronic parabiosis has a deleterious effect on lifespan in young animals, with no positive effect on older animals” by Iryna Pishel et al. Search for rejuvenation
Three-month heterochronic parabiosis has a deleterious effect on the lifespan of young animals, with no positive effect for older animals
Our previous study showed that an exchange of blood between heterochronic parabionts for 3 months did not rejuvenate the immune system of former partners. In addition, the young immune system became older and began to work according to the “old” principle. Does this forced aging affect all body systems in this model?
We checked corticosterone, testosterone, insulin-like growth factor (IGF-1), insulin, and thyroxine levels in the blood of heterochronic parabionts, but found no significant changes from to age-related witnesses.
Since many data support the possibility of brain, muscle, and other tissue rejuvenation using the heterochronic parabiosis model, as well as opposing data, we planned to assess the overall effect of this long-term blood exchange on the body’s aging rate. .
We measured the lifespan of animals whose blood was exchanged for 3 months and then disconnected. Median and maximum life expectancy decreased in young heterochronic parabionts compared to the isochronic control.
Ancient heterochronic parabionts showed only a slight trend towards increased median lifespan, but it was not statistically significant and maximum lifespan did not change compared to isochronic parabionts.
These data support our hypothesis that old blood contains factors capable of inducing aging in young animals. The mechanism of selectively suppressing the production of aging factors in the body could be a key research area for life extension.